Procedural Dermatology » Autologous growth factor

Autologous growth factor treatment or Platelet Rich Plasma (PRP) Therapy



The History of PRP Treatment


PRP first began being researched in the 1970s. It was first used in an open heart surgery procedure in Italy in 1987.

After successfully being used in that procedure, PRP grew in popularity starting in the mid-1990s. Today, Platelet rich plasma treatment has been applied to a variety of medical fields, including cosmetic surgery, dentistry, sports medicine, and pain management in many clinics around the world.   


Platelet Rich Plasma (PRP) is premium anti-aging skin treatment.

The treatment uses components called platelets contained in the patient's own blood.

Platelets contain an abundance of growth factors which stimulate stem cell production, collagen synthesis, proliferation of fibroblasts and angiogenesis to rejuvenate the skin.

PRP therapy has the effect of potentiating your innate natural healing power and tissue reorganization potential.



Platelet Growth Factor Stimulates Stem Cell Production


PRP (Platelet rich plasma) is defined as autologous blood with a concentration of platelets above baseline values.

• Average normal platelet count = 200,000/ul (normal range: 150,000 – 350,000/ul)
• PRP count= 1,000,000/ul (5x concentration) 


Blood is made up of 4 components including plasma, red blood cell (RBC), white blood cell (WBC), and platelets. 


A normal blood would be made up of 93% red blood cell, 6% platelets and 1% white blood cell. Through the use of centrifuge, the blood components are separated and the ratios are changed in PRP to 94% platelets and 
5% red blood cell.


Growth Factor Function


Growth Factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation.
Usually it is a protein or a steroid hormone.


Growth factors are important for regulating a variety of cellular processes and typically act as signaling molecules between cells. They often promote cell differentiation and maturation, which varies between growth factors. 



Examples of some Growth Factors 


   - Transforming Growth Factor-beta (TGF-β)

   -  Platelet Derived Growth Factor (PDGFa-b)

   - Epidermal Growth Factor (EGF)

   - Vascular Endothelial Growth Factor (VEGF)

   - Basic Fibroblast Growth Factor (BFGF) 

   - Connective Tissue Growth Factor (CTGF)



PRP injection procedure



Step 1: Blood is drawn from the patient 15-20 CC

Step 2: The collected blood is placed in a centrifuge that concentrates the platelets and growth factors into a smaller amount of plasma.

Step 3: The Platelet-Rich Plasma is then carefully injected into the site around your injured tendon.



PRP Therapy Advantages 


• No risk of transmissible infection and allergic reaction

• Natural result

• Longer duration of efficacy

• No need for skin incision

• Simple procedure

• Minimal discomfort

• Shorten downtime    


Depending on the severity of skin troubles, most patients require between one and three treatments. Each set of treatment is spaced 3 to 4 weeks apart. 


Pre-Injection Precautions


Avoid corticosteroid medications for 2 to 3 weeks prior to the procedure

- Stop taking non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin or ibuprofen, or arthritis medications such as Celebrex, a       week prior to the procedur

- Do not take anticoagulation medication for 5 days before the procedure

- Drink plenty of fluids the day before the procedur

Some patients may require anti-anxiety medication immediately before the procedure




- You may experience some discomfort, but do not despair! Your body is reacting in the normal and desired way to the sudden influx of platelets and healing factors.    


- You may want to ice and elevate your injury, perhaps even use Tylenol for pain relief. But ibuprofen, Advil and other NSAIDs will   produce the opposite reaction that the procedure is trying to create.  


- This treatment should be just a part of a rehabilitation planned by your doctors in order to get you back to your best. Finally, the PRP injection process may seem to be over-simplified, but it really is a very easy and effective way to treat tendonitis in all its forms. 



Who cannot have PRP treatment?


  • People who are suffering from skin diseases such as SLE, allergies, porphyria, cancer, severe metabolic and systematic disorders, abnormal platelet function, critical thomobocytopemia, haemodynamic instability, anti coagulation therapy and, underlying sepsis.  


  • Patients with severe anemia, low platelet count, abnormal platelet function, active systemic infection or those with an active cancer



PRP Injection for Facial Rejuvenation    


PRP stimulates your own collagen to grow for total facial rejuvenation rather than individual wrinkle improvement.


PRP is used for:- 


     -Volumizing faces that are beginning to look drawn

-Plumping out cheek indentations and soften under eye hollows 

-Improving the skin tone, tightness, and texture 

-Filling in areas where hyaluronic acid fillers cannot reach or are not safe to use.



Benefits of PRP Injection for Facial Rejuvenation


It can improve skin tone and texture, tighten skin, soften lines and pores.

Results begin to show 3-4 weeks after the treatment session and continue to improve with time. Three treatment sessions are generally recommended, spaced 1-2 months apart, to achieve the best outcome. 


How many treatments of PRP Injection for Facial Rejuvenation are required?


The initial treatment for PRP is one treatment a month for 3 to 4 months, then repeat treatments either 6-monthly or 12-monthly, depending on your skin and results.


PRP therapy can be combined with laser treatments, microdermabrasion, chemical peels, botox or derma filler for the best results.    


When will be able to see the result after PRP Injection for Facial Rejuvenaion? 


Results become visible at 3 weeks and increase gradually over ensuing months with improvement in the skin’s texture and tone. 



PRP Injection for Hair Loss


PRP contains growth factors that help to repair the injury and damaged caused by DHT hormones to your hair follicles, therefore helping to promote the regrowth of thicker and healthier hair. 


PRP will signal the body to send PLATELETS and PLASMA to the area, to repair the injured cells. Adding additional PRP increases the amount of repairing cells (platelets) and nutrients (plasma) in the hair loss region. This exposes the skin cells and the hair follicles to large amounts of healing platelets and nutrient rich plasma.



Benefits of PRP Injection for Hair Loss


      PREVENT & slow down the rate of hair loss, thinning, hair shedding & hair fall.

      REGROW thinning hair thicker, fuller and healthier.


      BOOST the health & condition of the scalp naturally


      ACTIVATE the regrowth of dormant hair follicles by encouraging the growth phase of your hair (anagen phase)

      HAIR TRANSPLANT PRP has shown to help prepare the area for a hair transplant + also to assist with the recovery and growth rate after receiving a hair transplant. 



How many treatments of PRP Injection for Hair Loss are required?


We recommend continuously 4 times treatments, spaced up to 4 weeks apart. Then it can be continue to enhance the result. Patients are recommended to receive a treatment every 1-3 months apart.


PRP therapy can be combined with laser treatments, hair growth lotion and pills for the best results. 



When will the hairs be regenerated after PRP Injection for Hair Loss?   


It will be within 1 or 2 months after the treatment.


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